An example of a text for an institution with a Federal Insurance Statement (FWA) that relies on another institution`s IRB/IEC (institutions can use this example as a guide to the development of their own agreement). SMART IRB was created to streamline the trust agreement process between institutions and is funded by the National Center for Advancing Translational Sciences (NCATS). SMART IRB was funded by the NIH to facilitate a single review of the IRB to comply with the NIH mandate. The SMART IRB-Master-Reliance agreement facilitates the authorisation process between participating institutions. A list of signatories to the SMART IRB agreement is available on the participating institution`s SMART IRB website. CHOP is the signatory to the SMART IRB agreement. 10/1/2019 – In April 2019, the IRB released important updates for the ongoing review process. Since then, we have been working to apply these updates to multiple situations. We have completed the review and review of ALL guidance and submission documents relating to reliance agreements. Please click here to check a summary of the changes If a Master Reliance Agreement does not exist, a trust agreement must be concluded with a single study for each study. The agreement may designate either chop`s IRB or the external site IRB as the verification IRB (SIRB). As a general rule, the audit IRB is located at the institution in which the IP is located in general.

A reliance agreement (also known as the Institutional Authorization Agreement or IAA) is an agreement signed by two or more institutions participating in the same human research project. The agreement allows one or more institutions to transfer the audit to another central or individual IRB. In general, this means that only an IRB will re-examine a single project for several collaborators in all institutions. Choose a tab below to learn more about when and how to incorporate a trust agreement into your project. UNC`s institutional profile contains basic information on UNC IRB and institutional processes and requirements when reliance agreements are considered or negotiated with cooperation sites. CHOP had many agreements on the reliability of research in other paediatric facilities.